Greg Harris

Greg M. Harris is an assistant professor in the Department of Chemical and Environmental Engineering in the College of Engineering and Applied Science at the University of Cincinnati. Dr. Harris completed his undergraduate degree at Iowa State University where he majored in Mechanical Engineering and followed with a Ph.D.in Chemical Engineering at the University of South Carolina. He then completed a postdoctoral fellowship at Princeton University in the Department of Molecular Biology where he researched the extracellular matrix in novel combinations with biomaterials as potential therapies for nerve injuries.
 
The lab’s research interests broadly include peripheral nerve and spinal cord injuries, cell-extracellular matrix interactions, biomaterials, and all facets of tissue engineering. This research area is a highly interdisciplinary field integrating many specialties such as engineering, chemistry, and biology. Our studies aim to systematically examine injury and disease states, and use engineering tools to understand and build viable clinical solutions.

B.S.: Iowa State University Ames, IA, 2008 (Mechanical Engineering)

Ph.D.: University of South Carolina Columbia, SC, 2013 (Chemical Engineering)

Grant: #R25076 Investigators:Harris, Gregory 04-01-2019 -03-31-2020 UC's URC Faculty Research Cost Support Awards Program Bioengineering a Neural Matrix for Traumatic Nerve Repair Role:PI $7,500.00 Active Level:Internal UC

Grant: #N/A Investigators:Harris, Gary; Harris, Gregory 06-01-2018 -06-30-2019 UC's Launch Awards URS Harris New Faculty Development Award – 2017/18 Role:PI $2,500.00 Closed Level:Internal UC

Grant: #W81XWH-21-1-0174 Investigators:Esfandiari, Leyla; Harris, Gregory 03-01-2021 -02-29-2024 Department of the Army Medical Research Acquisition Activity Next-Generation Smart Scaffolds for Regenerative Peripheral Nerve Therapeutics Role:PI $115,145.00 Awarded Level:Federal

Grant: #DMR-2104639 Investigators:Esfandiari, Leyla; Harris, Gregory 06-15-2021 -05-31-2024 National Science Foundation Bioactive, piezoelectric materials for real time monitoring and stimulation of neural networks Role:PI 450000.00 Awarded Level:Federal

Grant: #R01CA249737 Investigators:Abdelmalek, Zalfa; Chaudhary, Rekha; Harris, Gregory; Xie, Changchun; Zhang, Yuhang 06-15-2021 -05-31-2026 National Cancer Institute Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape Role:Collaborator 375431.00 Awarded Level:Federal

Grant: #R01NS134804 Investigators:Collar, Ryan; Esfandiari, Leyla; Harris, Gregory; Niu, Liang; Pixley, Sarah 01-01-2024 -12-31-2028 National Institute of Neurological Disorders and Stroke Developing multi-cue piezoelectric PVDF-TrFE biomaterials for peripheral nerve repair Role:PI 441060.00 Awarded Level:Federal

Peer Reviewed Publications

Harris, Greg M; Madigan, Nicolas N; Lancaster, Karen Z; Enquist, Lynn W; Windebank, Anthony J; Schwartz, Jeffrey; Schwarzbauer, Jean E (2017. ) Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix.Matrix biology : journal of the International Society for Matrix Biology, , 60-61 ,176-189 More Information

Rutledge, Katy; Cheng, Qingsu; Pryzhkova, Marina; Harris, Greg M; Jabbarzadeh, Ehsan (2014. ) Enhanced differentiation of human embryonic stem cells on extracellular matrix-containing osteomimetic scaffolds for bone tissue engineering.Tissue engineering. Part C, Methods, , 20 (11 ) ,865-74 More Information

Pryzhkova, Marina V; Aria, Indrat; Cheng, Qingsu; Harris, Greg M; Zan, Xingjie; Gharib, Morteza; Jabbarzadeh, Ehsan (2014. ) Carbon nanotube-based substrates for modulation of human pluripotent stem cell fate.Biomaterials, , 35 (19 ) ,5098-109 More Information

Harris, Greg M; Piroli, Maria E; Jabbarzadeh, Ehsan (2014. ) Deconstructing the Effects of Matrix Elasticity and Geometry in Mesenchymal Stem Cell Lineage Commitment.Advanced functional materials, , 24 (16 ) ,2396-2403 More Information

Cheng, Qingsu; Harris, Greg M; Blais, Marc-Olivier; Rutledge, Katy; Jabbarzadeh, Ehsan (2014. ) Alignment of Carbon Nanotubes: An Approach to Modulate Cell Orientation and Asymmetry.Nano LIFE, , 4 (1 ) , More Information

Cheng, Qingsu; Blais, Marc-Olivier; Harris, Greg M; Harris, Greg; Jabbarzadeh, Ehsan (2013. ) PLGA-carbon nanotube conjugates for intercellular delivery of caspase-3 into osteosarcoma cells.PloS one, , 8 (12 ) ,e81947 More Information

Harris, Greg M; Shazly, Tarek; Jabbarzadeh, Ehsan (2013. ) Deciphering the combinatorial roles of geometric, mechanical, and adhesion cues in regulation of cell spreading.PloS one, , 8 (11 ) ,e81113 More Information

Harris, Greg M; Rutledge, Katy; Cheng, Qingsu; Blanchette, James; Jabbarzadeh, Ehsan (2013. ) Strategies to direct angiogenesis within scaffolds for bone tissue engineering.Current pharmaceutical design, , 19 (19 ) ,3456-65 More Information

Pryzhkova, Marina V.; Harris, Greg M.; Ma, Shuguo; Jabbarzadeh, Ehsan (2013. ) Patterning Pluripotent Stem Cells at a Single Cell Level.Journal of Biomaterials and Tissue Engineering, , 3 (4 ) ,461 More Information

Smith, Corinne S; Orkwis, Jacob A; Bryan, Andrew E; Xu, Zhenyuan; Harris, Greg M (2022. ) The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity.European journal of cell biology, , 101 (4 ) ,151277 More Information

Orkwis, Jacob A; Wolf, Ann K; Mularczyk, Zachary J; Bryan, Andrew E; Smith, Corinne S; Brown, Ryan; Krutko, Maksym; McCann, Adam; Collar, Ryan M; Esfandiari, Leyla; Harris, Greg M (2022. ) Mechanical stimulation of a bioactive, functionalized PVDF-TrFE scaffold provides electrical signaling for nerve repair applications.Biomaterials advances, , 140 ,213081 More Information

Xu, Zhenyuan; Orkwis, Jacob A; Harris, Greg M (2021. ) Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases.International journal of molecular sciences, , 22 (9 ) , More Information

Jafari, Mina; Sriram, Vishnu; Xu, Zhenyuan; Harris, Greg M; Lee, Joo-Youp (2020. ) Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy.Carbohydrate polymers, , 249 ,116837 More Information

Orkwis, Jacob A; Wolf, Ann K; Shahid, Syed M; Smith, Corinne; Esfandiari, Leyla; Harris, Greg M (2020. ) Development of a Piezoelectric PVDF-TrFE Fibrous Scaffold to Guide Cell Adhesion, Proliferation, and Alignment.Macromolecular bioscience, , 20 (9 ) ,e2000197 More Information

Cady, Emily; Orkwis, Jacob A; Weaver, Rachel; Conlin, Lia; Madigan, Nicolas N; Harris, Greg M (2020. ) Micropatterning Decellularized ECM as a Bioactive Surface to Guide Cell Alignment, Proliferation, and Migration.Bioengineering (Basel, Switzerland), , 7 (3 ) , More Information

Xu, Zhenyuan; Orkwis, Jacob A; Harris, Greg M (2020. ) Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification.Journal of visualized experiments : JoVE, , (160 ) , More Information

Xu, Zhenyuan; Orkwis, Jacob A; DeVine, Braden M; Harris, Greg M (2020. ) Extracellular matrix cues modulate Schwann cell morphology, proliferation, and protein expression.Journal of tissue engineering and regenerative medicine, , 14 (2 ) ,229-242 More Information

Chen, Jeffrey W; Lim, Kelly; Bandini, Stephen B; Harris, Greg M; Spechler, Joshua A; Arnold, Craig B; Fardel, Romain; Schwarzbauer, Jean E; Schwartz, Jeffrey (2019. ) Controlling the Surface Chemistry of a Hydrogel for Spatially Defined Cell Adhesion.ACS applied materials & interfaces, , 11 (17 ) ,15411-15416 More Information

Harris, Greg M; Raitman, Irene; Schwarzbauer, Jean E (2018. ) Cell-derived decellularized extracellular matrices.Methods in cell biology, , 143 ,97-114 More Information

Pryzhkova, Marina V; Harris, Greg M; Ma, Shuguo; Jabbarzadeh, Ehsan (2013. ) Patterning Pluripotent Stem Cells at a Single Cell Level.Journal of biomaterials and tissue engineering, , 3 (4 ) ,461-471 More Information

2014-2017 Postdoctoral Research Fellow, Peripheral and spinal cord nerve injuries affect millions of people each year. In many instances, nerve repair requires regeneration of nerve fibers across a large gap created by the injury. Using a tissue engineering approach that combines biomaterials with extracellular matrix, I investigated the effects of a cell-secreted extracellular matrix on neurite alignment and extension., Princeton University, , Princeton, NJ

Harris Lab

Academic - 880 Mantei Center
2901 Woodside Drive
Cincinnati  Ohio, 45221