Leyla Esfandiari
Asst Professor
CEAS - Elec Eng & Computer Science 0018
Engineering Research Cntr 383
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Ph.D.Bioengineering ,University of California Los Angeles (UCLA),Los Angeles CA,2014
MS.c. Biomedical Engineering ,University of California Irvine (UCI),Irvine CA,2008
B.SElectrical Engineering ,California State University ,Long Beach CA,2006

Research and Practice Interests

Rapid, sensitive, portable and robust detection of biomolecules is of significant interest in a range of diverse health-related applications such as screening for oncogenes in cancer, drug screening in pharmaceutical industry, pathogen microbe identification in food and water safety, paternity test in forensic science and detection of bio-warfare agent in homeland security. However, the majority of the conventional detection methods are relying on tedious sample preparation techniques, target amplification by polymerase chain reaction (PCR), enzyme and fluorescent labeling, or sophisticated/bulky instrumentation. To address these shortcomings, Esfandiari’s research group is utilizing nanotechnology and microfabrication techniques to develop reagent-free handheld and wearable diagnostic devices with high sensitivity, selectivity and stable shelf life.
Additionally, she is interested in design and implementation of bio-platforms for investigating the effect of quantitatively controlled applied cues on various cell types to study the cell signaling pathways. Studying the micron-scale biological units under controlled heterogeneous environmental cues is crucial for understanding tissue functions and ultimately the organ system. The systematic investigation of basic biology under controlled applied forces has potential application in preventive, therapeutic, and regenerative medicine. 

Professional Summary

Dr. Esfandiari joined the College of Engineering and Applied Science at the University of Cincinnati as an Assistant Professor with dual appointment in Electrical Engineering and Biomedical Engineering. She completed her doctoral degree in Bioengineering from the University of California Los Angeles (UCLA). She earned her Master of Science in Biomedical Engineering from the University of California Irvine with focus on design and development of a microfluidic platform for studying neurogenesis. Also, she obtained her Bachelor of Science in Electrical Engineering from California State University.
While at UCLA, Esfandiari also conducted research for the California Nano-System Institution (CNSI), and the Orthopedic Surgery Laboratory. During her academic training, Esfandiari has spent time giving back by leading and training graduate and undergraduate students in conducting research and experiments. Besides her academic practice, she has 4 years of industrial experience at  Applied Medical Co and Honeywell Inc.
Dr. Esfandiari has a multidisciplinary research background in development of Microelectromechanical Systems (MEMS) for studying cell mechanics, nano-surface chemistry and development of molecular biosensors. At University of Cincinnati, she is leading the Integrative BioSensing Laboratory with the main focus on design and development of miniaturized biosensors and bio-platforms for point-of-care (POC) medical diagnostics, preventive and therapeutic medicine. 

Publications (Click the link below)